production, formulation, quality control and primary biological studies of [18f]kf for skeletal pet scanning [persian]

[18f]kf, considered as a reference standard for positron emission tomography of the skeletal system, was produced by the bombardment of enriched water ([18o]h2o>95%) with high energy protons in nrcam cyclotron. after the extraction of fluoride from enriched water as kf, and passing it through microbial filter and fine adjustment of acidity and osmolality, it was converted into an injectable form. pre-clinical investigations and biological controls were performed to determine radioisotope distribution in laboratory rats, thus suitable information was gathered for imaging in humans. this radiopharmaceutical was proved to be quite safe and of high quality as a result of testing in laboratory rats.